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posted 04. April 2002 15:09
Nature 416 (2002): 499-506
An Extensive Network of Coupling Among Gene Expression Machines
by Tom Maniatis and Robin Reed
Abstract: Gene expression in eukaryotes requires several multi-component cellular machines. Each machine carries out a separate step in the gene expression pathway, which includes transcription, several pre-messenger RNA processing steps and the export of mature mRNA to the cytoplasm. Recent studies lead to the view that, in contrast to a simple linear assembly line, a complex and extensively coupled network has evolved to coordinate the activities of the gene expression machines. The extensive coupling is consistent with a model in which the machines are tethered to each other to form 'gene expression factories' that maximize the efficiency and specificity of each step in gene expression.
[ 04 April 2002, 15:13: Message edited by: Moderator ]
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