ISCID News Editor
Member # 1417
posted 03. February 2005 20:39
Source: Nature Reviews - Microbiology
Paragraph 1 and extract of Paragraph 2:
The FtsZ protein is essential for bacterial cell division, and polymerizes into a ring structure that constricts when the cell divides. It is the prokaryotic homologue of eukaryotic tubulin^, and previous studies have shown that it can polymerize in a GTP^ -dependent manner similar to that of tubulin. Formation of the tubulin protofilament is known to involve interaction of the C-terminal domain (involving the T7 loop) of one subunit with the GTP-binding domain of another and, owing to the similarities between the two proteins, it has been assumed that FtsZ would polymerize in a similar manner.
Now, Jan Löwe and co-workers provide experimental evidence that FtsZ forms the same protofilament as tubulin.
Read full review at Nature
Read the original Nature research article at Jan Lowe laboratory group, Cambridge
Visit research groups at MRC-LMB
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[ 03. February 2005, 20:40: Message edited by: ISCID News Editor ]