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posted 05. January 2006 19:42
Source: Rockefeller University Newswire
Posted: January 4, 2006
New ‘PhyloGibbs’ software helps scientists make sense of DNA
Kristine Kelly
Paragraph's 4 and 5:
The computer program, called PhyloGibbs, which Siggia and Nimwegen developed with former postdoc Rahul Siddharthan, builds on previous software designed to identify where these regulatory molecules bind to DNA. Like its predecessors, PhyloGibbs compares DNA from multiple species in order to identify areas in which the genetic code^ is statistically similar and filter segments that are most likely to be of interest to scientists.
This approach, however, has been complicated by several factors. First, such inter-species conservation of DNA is not always indicative of function; in organisms that are closely related evolutionarily, some segments of the sequence may be alike simply because the sequences have not diverged sufficiently. Second, not all functional segments are conserved because many mutations either do not affect function or are compensated for by other mutations.
Read the full press release at Rockefeller University Newswire
[Emphases added by ISCID News Editor]
[Link-underlined terms with ^ indicate linked entry in ISCID Encyclopedia of Science and Philosophy as added by ISCID News Editor]
[ 05. January 2006, 19:46: Message edited by: ISCID News Editor ]
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