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Author
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Topic: Intelligently Designing Immunity
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Nel
Member
Member # 614
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posted 14. April 2003 16:10
Charlie wrote:
quote:
No. In a V1-V2-J2-C2 system (where "-" are intersegmental, noncoding intervals, or introns in the J-C case) you'd simply get V1 or V2 independently rearranging onto J2, giving rise to V1J2 or V2J2 rearrangements, both equally functional in 1/3 or the cases (and frameshifted in 2/3).
Well first I'm not talking about the V1-V2-J2-C2 case, although maybe we can talk about that. I'm talking about the V1-V2-D2-J2-C2 case. Secondly, I was wondering if you could tell me if the shark system can distinguish bewteen two V segments when it all it does is rearrange within it's cluster? Although this could be possible with an already functioning Rag-RSS-receptor system. But without that, we are back to the frameshift-useless antibody problem. Unless you are advocating that the Rag genes jumped into the shark genome as a fully functional machine, which makes sense to me.
I guess, this would suggest that this germline arrangement is truly useless without the recombination machine.
[ 24. April 2003, 17:13: Message edited by: Nelson_Alonso ]
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