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Author Topic: Redundant Genes & Backup Systems
David L. Hagen
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Member # 323

Icon 1 posted 08. May 2006 22:32      Profile for David L. Hagen   Email David L. Hagen   Send New Private Message       Edit/Delete Post 
I propose exploring some fascinating discoveries on Redundant Genes and Backup Systems described by Peter Borger at:
Can Darwinian Theory be Falsified p 5

Peter
I am fascinated by your comments on Redundant genes and their strong support for ID and devestating effect evolution.

quote:
Redundant genes have only recently been discovered. That is because their existence cannot be deduced from classic genetic experiments (although some Mendelian genetics can be understood from redundancies). These genes are usually part of regulatory networks, and the peculiar thing is that they can be inactivated without any effect on reproductive success (=fitness). Genetic redundancy only became apparent when biologists interested in gene function developed gene-knockout strategies. With the remarkable observation that most knockouts do not have a phenotype.

Because there is NO association with gene duplication and genetic redundancy (this has been shown over and over in many organisms, now) this is the deathblow to any long-age evolutionary theory. Darwinian theory dramatically fails on another front too: selection. Natural selection cannot explain the existence of back up systems, which is essentially what genetic redundancy is. Just like sexual reproduction, as you argue, genetic redundancy creates robustness of organisms, and provides another level of stability.

quote:
We can only understand the biological discoveries of the last decade from the perspective of recent creational events (genetic redundancy with no association with gene duplication, rapid deterioration of genomes, high mutations rates within species, soft tissue recovery from dinosaurs, etc).
I would appreciate your amplifying on your comments, hopefully into a review paper.
Do you have any books, reviews or publications that summarize or detail such redundant genes and backup systems?

Such redunancy or backup fits neatly into a general theory of ID with predictive power I have been working on. From your brief description, may I posit the following:
Proposed Intelligent Design Principle:

"Provide backup systems for system critical function to ensure mission success."

Proposed ID Prediction:
"There will likely be redundant or backup genes for mission critical components and systems."

Ther are many examples of such applications in engineering. There appear to be many examples in biology of such redundancy. e.g., the degeneracy (or "redundancy") built into the genetic alphabet, dual strand DNA, duplication of genes in the Y chromosome etc.

I look forward to learning more about recent discoveries that will flesh this out.

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peter borger
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Icon 1 posted 09. May 2006 04:53      Profile for peter borger   Email peter borger   Send New Private Message       Edit/Delete Post 
Dear David,

I review genetic redundancy in three chapters of the book I am currently finishing. Working title: GUToB, a general & universal theory of biology.

If there is interest I would be happy to prepublish one of the chapters in the PCID.

peebee

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Bruce Fast
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Icon 1 posted 14. May 2006 10:13      Profile for Bruce Fast   Email Bruce Fast   Send New Private Message       Edit/Delete Post 
Hello PB. I for one am highly interested in your book, and if possible, a prerelease chapter.
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