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Genomic Library

A complete collection of molecules in a stable form representing some aspect of an organism is called a library in molecular biology. A genomic library contains an example of each DNA sequence found in a particular genome (or the hereditary information of an organism), broken into manageable fragments.

With complete information about this for a specific organism, researchers can perform a variety of experiments on the DNA to determine the actions and interactions of separate genes along the strand. They can also compare the genomic library of healthy and unhealthy individuals of the same species to see where differences in genetic coding may have led to maladaptive mutations.

In physical reality, a genomic library for humans is a collection of bacteria, typically E. coli, each carrying a manageable and usable snippet of DNA from the human genome. The DNA is prepared by digesting it with a restriction enzyme, then repackaging the separated segments of the DNA for insertion into the bacteria using lamda phage vectors. This creates a basic unamplified library. An amplified library is one where the bacteria have been allowed to multiply and create additional copies of each section of the DNA.

Web Resources On Genomic Library

Construction of a Human Genomic Library
Molecular Genetics: Libraries

Book Resources On Genomic Library

Emerging Technologies in Protein and Genomic Material Analysis by Gyorgy Marko-Varga and Peter Oroszlan
Bacterial Artificial Chromosomes: Library Construction, Physical Mapping, and Sequencing by Zhao &Stodolsky (Editors)

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