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Major Histocompatibility Complex

The region of chromosome six that encodes the two classes of proteins responsible for presenting peptide based antigens on the surface of nucleated cells. Three genes encode for the Class I MHC proteins HLA-A, HLA-B and HLA-C, which present antigens to Killer T Cells, and for Class II MHC proteins, which are used only by immune system cells such as macrophages and present antigens to Helper T Cells.

Web Resources On Major Histocompatibility Complex

PLoS Medicine: Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness after Vaccination Using a Functional Microarray
PLoS Pathogens: Using the TAP Component of the Antigen-Processing Machinery as a Molecular Adjuvant
PLoS Pathogens: Inhibition of MHC Class I Is a Virulence Factor in Herpes Simplex Virus Infection of Mice

Book Resources On Major Histocompatibility Complex

How the Immune System Works by Lauren Sompayrac

Editor(s): Long, B.

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