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Oncolysate

Oncolysates are extracts of cancer cells that are subsequently infected with lytic viruses. The resulting combination of cancer cell proteins and virus proteins is re-introduced into the original cancer as immunotherapy against the tumor. Oncolysates are being studies as possible cancer vaccines.

Once the virus has been combined with the cancer, it can work against the cancer in several different ways. One is by stimulating the immune system of the human or animal it is injected into. The immune cells respond to the viral proteins, and build up quickly to attack the injected proteins. But they also develop new immune cells to respond to the cancer proteins, and will attack not only the injected mixture but also the cancer cell the extracts came from. These immune cells can be used as a vaccine against that type of cancer in the future.

Some researchers are also studying the possibility of using the lysed cancer proteins as a way to deliver cell-killing viruses directly to the cancer tumor. This more direct method is much trickier, as the virus must attack only the cancer and nothing else in the body.

Web Resources On Oncolysate

Viral oncolysate vaccine for stimulating the immune mechanism of mammals to species-specific tumors
Early antiviral antibody response after immunization with viral oncolysate

Book Resources On Oncolysate

The Conquest of Cancer: Vaccines and Diet by Virginia Livingston-Wheeler
Lovely Cancer Vaccine - The Hasumi Cancer Vaccine by Journalists for the Study of Cancer

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