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RNA

Ribonucleic Acid. A single stranded polynucleotide, RNA is so named because the molecular structure of its constituent nucleotides incorporate a ribose carbohydrate (in contrast to DNA, whose nucleotides incorporate a deoxyribose carbohydrate). There are four nucleotides in RNA, which are differentiated according to which base is bound to the carbohydrate in each - Adenine (A), Cytosine (C), Guanine (G) or Uracil (U). The third constituent part of nucleotides - a phosphate group - allows them to bind together into the polynucleotide called RNA.

There are three main types of RNA:

  1. mRNA or messenger RNA is the RNA produced by the transcription of DNA leading and lagging strands by DNA polymerase. mRNA is then translated into proteins by ribosomes.

  2. rRNA is the variety of RNA that combines with different proteins to form ribosomes - the mRNA to protein translators - themselves.

  3. tRNA or transfer RNA are short RNA sequences that act as intermediaries or adapters in ribosomal mRNA to protein translation


Other types of RNA have been discovered, the most notable of which is microRNA, which is a kind of helper RNA in mRNA translation. Geneticists are just learning about the functions of specific microRNAs. Recent work Pedersen et. al. which compares the human genome with other vertebrate genomes to identify deeply conserved functional RNA sequences has provided evidence for many new human functional RNAs.


Web Resources On RNA

ISCID News and Features - miRNA gene expression regulation algorithm based on evolutionary conservation
ISCID News and Features - A population-based statistical approach identifies parameters characteristic of human microRNA-mRNA interactions
ISCID News and Features - Method for identification of functional RNA structures based on phylogenetic analysis


Book Resources On RNA

Darwin's Black Box by Michael J. Behe

Editor(s): Long, B.

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