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SELEX

SELEX, or Systematic Evolution of Ligands by EXponential enrichment, is a procedure in which an initial pool of randomized polynucleotides (RNA or DNA, single stranded) is created, containing on the order of 10^15 molecules of a fixed length. The pool is then screened for some desired characteristic (for example, binding affinity for ATP). The molecules that are selected in this way are used as “parents” in the synthesis (with mutation) of a new pool of molecules, and the process repeats with more rounds of selection and amplification. The result of SELEX is a set of highly functional molecules of DNA or RNA that perform their selected function.

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