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Zosuquidar Trihydrochloride

Zosuquidar trihydrochloride (also called LY335979) is a newly-discovered compound that may be able to reverse the body’s resistance to chemotherapy. Its chemical composition is difluorocyclopropyl quinoline. It is found naturally in several organs, including the liver, small intestine, skin, brain, and blood vessels.

Zosuquidar trihydrochloride binds easily with P-glycoproteins to inhibit drug resistance that has been caused by the acclimatization of P-glycoproteins to these drugs. This makes ATP processes that may not have functioned well before, work properly; among these processes is the carrying of medicines out of cells by attaching to them and transporting them to the outside of the cellular membrane. During this process, it also prevents intacellular accumulation of a number of different natural and artificial cytotoxic agents.

Part of what this does is make cancer cells that were resistant to chemotherapy suddenly susceptible. Currently, Phase 3 testing is going on in the United States for this particular action.

Drugs with similar action include tariquidar and laniquidar.

Web Resources On Zosuquidar Trihydrochloride

A Phase I Trial of a Potent P-Glycoprotein Inhibitor, Zosuquidar Trihydrochloride
NCI: Zosuquidar trihydrochloride

Book Resources On Zosuquidar Trihydrochloride

New Drug Development by Chandrahas Sahajwalla (Ed.)
Computer Applications in Pharmaceutical Research and Development by Sean Ekins (Ed.), Binghe Wang (Ed.)

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